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sulfisoxazole
- Development stage
- Unknown
- Lead developer
- Roche
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Ophthalmic, Intravenous, Vaginal
01
Overview
Sulfisoxazole is a synthetic sulfonamide antibiotic used to treat or prevent a variety of bacterial infections, including urinary tract infections, otitis media (ear infections), and meningitis. It acts as a competitive inhibitor of the enzyme dihydropteroate synthase in bacteria, thereby blocking the synthesis of dihydrofolic acid from para-aminobenzoic acid (PABA), which is essential for folic acid production and bacterial growth. Sulfisoxazole is effective against many gram-positive and gram-negative organisms but will not work for viral infections such as colds or flu[1][2][3][4][6].
- Brand names
- GantrisinGantrisin PediatricTruxazole
02
Targets
DHPS (Dihydropteroate synthase)
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