Drug intelligence / Profile preview

sulfonylurea + pioglitazone + liraglutide

Development stage
Unknown
Lead developer
Novo Nordisk
Modality
Peptides, Small Molecules
Administration
Oral, Subcutaneous
01

Overview

A triple combination therapy for type 2 diabetes mellitus that combines three different mechanisms of action. Sulfonylureas stimulate insulin secretion from pancreatic beta cells, pioglitazone improves insulin sensitivity by activating PPAR-gamma receptors, and liraglutide is a GLP-1 receptor agonist that enhances glucose-dependent insulin secretion and suppresses glucagon secretion. This combination has shown significant efficacy in improving glycemic control in patients with poorly controlled diabetes.

02

Targets

SUR1 (Sulfonylurea receptor 1)PPARG (Peroxisome proliferator-activated receptor gamma)GLP1R (GLP-1R)

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