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sulforaphane-rich broccoli sprout extract
- Development stage
- Unknown
- Lead developer
- Andrew Zimmerman
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Sulforaphane-rich broccoli sprout extract is a botanical preparation containing high levels of glucoraphanin and its active metabolite, sulforaphane. Sulforaphane is a potent inducer of the **Nuclear factor erythroid 2-related factor 2 (Nrf2)** pathway, which orchestrates the cellular antioxidant response and reduces oxidative stress and neuroinflammation. This extract has been evaluated in clinical trials, particularly by researchers like Dr. Andrew Zimmerman, for its potential to improve core behavioral symptoms in individuals with **autism spectrum disorder (ASD)**. The mechanism is thought to involve the upregulation of cytoprotective genes that address the physiological abnormalities often associated with autism, such as mitochondrial dysfunction and redox imbalance.
- Brand names
- Avmacol
- Other names
- Broccoli Sprout ExtractBSESFN-rich BSE
02
Targets
KEAP1 (Kelch-like ECH-associated protein 1)HDAC (HDAC family)NF-κB
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