sulfosuccinimidyl oleate

Sulfosuccinimidyl oleate (SSO) is a small molecule that acts as a potent and irreversible inhibitor of CD36, also known as fatty acid translocase (FAT). By covalently binding to the CD36 receptor, SSO blocks the uptake of long-chain fatty acids into cells, thereby modulating lipid metabolism and downstream signaling pathways. It is widely utilized as a pharmacological research tool to investigate the role of CD36-mediated lipid transport in various pathological conditions. In oncology, SSO has been studied for its ability to suppress tumor relapse, inhibit metastasis, and overcome drug resistance in cancers such as hepatocellular carcinoma, triple-negative breast cancer, and prostate cancer by disrupting lipid-driven metabolic reprogramming. Additionally, SSO has shown potential in preclinical models for treating inflammatory skin diseases like psoriasis, obesity-related metabolic syndrome, and severe acute pancreatitis by reducing lipid accumulation and associated oxidative stress or inflammation.

Other names

sulfosuccinimidyl oleate sodiumN-sulfosuccinimidyl oleate