sulphadoxine + pyrimethamine + metronidazole

This is a combination of three drugs: - **Sulfadoxine** (a sulfonamide antibiotic) and **pyrimethamine** (an antiprotozoal) are most commonly used together as an antimalarial combination, known for inhibiting sequential steps in folate synthesis in protozoa. This dual inhibition results in a synergistic effect against *Plasmodium* species and is also being explored for activity against certain bacterial infections such as bacterial vaginosis[1][5][6]. - **Metronidazole** is a nitroimidazole antibiotic effective primarily against anaerobic bacteria and certain protozoa. It works by causing DNA strand breakage after reduction within susceptible organisms. The triple combination has no established brand or regulatory approval as a fixed-dose product but may be considered experimentally or off-label for conditions where both malaria and anaerobic/protozoal infections co-exist, or where drug repurposing is under investigation (e.g., resistant bacterial vaginosis)[1]. Each component acts via distinct mechanisms—sulphadoxine inhibits dihydropteroate synthase, pyrimethamine inhibits dihydrofolate reductase, and metronidazole disrupts DNA synthesis.

Other names

sulfadoxine + pyrimethamine + metronidazoleSP + metronidazole