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Sulprostone
- Development stage
- Unknown
- Lead developer
- Clearside Biomedical
- Modality
- Small Molecules
- Administration
- Suprachoroidal, Intramuscular, Intravenous, Intra-amniotic, Extraovular
01
Overview
Sulprostone is a synthetic analog of prostaglandin E2 (PGE2). It functions as a potent and selective agonist for prostaglandin EP3 receptors and a weaker agonist for EP1 receptors. This binding leads to increased intracellular calcium levels and decreased cyclic adenosine monophosphate (cAMP), primarily stimulating uterine contractions. Historically, Sulprostone has been utilized in obstetrics and gynecology for inducing labor, managing postpartum hemorrhage, and for medical abortion. More recently, it has been investigated for its potential in treating glaucoma, with preclinical efforts exploring its delivery via the suprachoroidal space using a microinjector.
- Brand names
- NaladorCergem
- Other names
- SulprostonumSulprostona
02
Targets
PTGER1 (Prostaglandin E Receptor 1)PTGER3 (Prostaglandin E2 receptor EP3 subtype)
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