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Sumagen Ebola vaccine

Development stage
Preclinical
Lead developer
Merck
Modality
Viral Vector Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Sumagen Canada is developing a viral vector vaccine for the prevention of Ebola virus disease. The vaccine utilizes a recombinant Vesicular Stomatitis Virus (rVSV) platform to create pseudotyped virions that display both the VSV glycoprotein and the Ebola virus glycoprotein (GP) on their surface. By delivering the gene encoding the Ebola GP, the vaccine triggers the host's immune system to produce neutralizing antibodies and activate T-cell responses against the Ebola virus. This dual-glycoprotein display is intended to enhance the immunogenicity and stability of the vaccine candidate. Currently in the research and development stage, this candidate aims to provide a robust prophylactic option against Ebola virus infections.

Other names
Sumagen Canada-Ebola glycoprotein-viral vector vaccine-Ebola virus diseaseVSV-based Ebola VaccinerVSV pseudotype Ebola vaccine
02

Targets

Zaire ebolavirus glycoprotein

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