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Drug intelligence / Profile preview
sunitinib + pemetrexed
- Development stage
- Phase 2
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Sunitinib + pemetrexed is a combination therapy that has been investigated for the treatment of advanced solid malignancies. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor that blocks cellular signaling by targeting multiple RTKs including PDGF-R, VEGF-R, KIT (CD117), RET, CSF-1R, and flt3. Pemetrexed is a folate analog chemotherapy drug that works by blocking the action of certain substances in the body that may help cancer cells multiply. The combination has been studied in clinical trials, particularly in patients with non-small cell lung cancer (NSCLC) and mesothelioma.
- Other names
- sunitinib malatepemetrexed disodium
02
Targets
CSF1R (Macrophage colony-stimulating factor receptor)DHFR (Dihydrofolate reductase)FLT3 (Fms related receptor tyrosine kinase 3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRB (Platelet-derived growth factor receptor beta)RET (Rearranged during transfection receptor tyrosine kinase)TS (Thymidylate synthase)VEGFR2 (Vascular endothelial growth factor receptor 2)GART (GAR transformylase)
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