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SupCBAKK
- Development stage
- Preclinical
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
SupCBAKK is a postbiotic formulation consisting of the mixed fermented metabolites (supernatants) derived from the probiotics *Clostridium butyricum* (CB) and *Akkermansia muciniphila* (AKK). It is being investigated as a therapeutic intervention for inflammatory bowel disease (IBD) and colorectal cancer (CRC). SupCBAKK functions through a multi-targeted approach by modulating immune responses, repairing the intestinal mucosal barrier, and ameliorating gut dysbiosis. Preclinical research indicates that this combination of metabolites exhibits significant synergistic effects compared to individual components and can enhance the efficacy of immune checkpoint inhibitors, such as anti-PD-L1, by increasing tumor sensitivity to immunotherapy and amplifying antitumor immune responses.
- Other names
- mixed fermented metabolites of Clostridium butyricum and Akkermansia muciniphilaSupCB + SupAKK
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