Drug intelligence / Profile preview

Super-Curcumin

Development stage
Unknown
Lead developer
America's Finest
Modality
Small Molecules
Administration
Oral
01

Overview

Super-Curcumin is a proprietary dietary supplement formulation developed by American Finest Inc., consisting of a standardized extract of *Curcuma longa* known as Curcumin C3 Complex combined with BioPerine, a standardized extract of black pepper (*Piper nigrum*). Curcumin C3 Complex contains three main curcuminoids: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. BioPerine contains piperine, which acts as a bioavailability enhancer by inhibiting metabolic pathways such as glucuronidation in the liver and intestinal wall, significantly increasing the systemic absorption of curcumin. Clinically, Super-Curcumin has been investigated as an adjunctive treatment for schizophrenia and schizoaffective disorder. Its therapeutic potential is attributed to its anti-inflammatory effects through the inhibition of inducible nitric oxide synthase (iNOS) and its ability to act as an epigenetic modulator by inhibiting histone acetyltransferases.

Brand names
Super-Curcumin
Other names
Curcumin C3 Complex + BioperineSuper Curcumin
02

Targets

NOS2 (Nitric Oxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)GLO1 (Glyoxalase 1)LY96 (Myeloid differentiation factor 2)HDAC8 (Histone Deacetylase 8)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)KAT (Histone acetyltransferases)

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