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Superoxide dismutase (SOD) is an enzyme found in all living cells that catalyzes the conversion of superoxide radicals into hydrogen peroxide and molecular oxygen, playing a critical role in the body's antioxidant defense system. It helps protect cells from oxidative damage by neutralizing potentially harmful oxygen molecules. SOD exists in several forms including copper-zinc SOD, manganese SOD, iron SOD, and nickel SOD, distributed throughout different cellular compartments. The enzyme has been investigated for its anti-inflammatory and antioxidant properties in various conditions including osteoarthritis, rheumatoid arthritis, and idiopathic pulmonary fibrosis.
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