Drug intelligence / Profile preview

SurBred

Development stage
Approved
Lead developer
Talphera
Modality
Small Molecules
Administration
Sublingual
01

Overview

SurBred is a sublingual tablet formulation of sufentanil citrate, a highly potent synthetic opioid analgesic. Developed for the management of moderate-to-severe acute pain in a medically supervised setting, it utilizes a specialized delivery system to administer the drug via the oral mucosa. Sufentanil acts as a selective agonist at the mu-opioid receptor, providing analgesic effects significantly more potent than fentanyl or morphine. By utilizing the sublingual route, SurBred achieves rapid systemic absorption and avoids first-pass hepatic metabolism, offering a non-invasive alternative to intravenous opioid administration. The product was originally developed by AcelRx Pharmaceuticals (now Talphera) and is licensed to Yichang Humanwell Pharmaceutical for the Chinese market.

Brand names
SurBredDsuvia
Other names
sufentanil sublingual tabletsufentanil citrate
02

Targets

DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)

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