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surufatinib + standard chemotherapy
- Development stage
- Unknown
- Lead developer
- HUTCHMED
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
This combination therapy involves surufatinib, an oral small-molecule tyrosine kinase inhibitor, administered alongside standard chemotherapy regimens (either Etoposide plus Carboplatin or Capecitabine plus Temozolomide). Surufatinib targets vascular endothelial growth factor receptors (VEGFR 1-3), fibroblast growth factor receptor 1 (FGFR1), and colony-stimulating factor 1 receptor (CSF-1R), thereby inhibiting angiogenesis and modulating the tumor immune microenvironment. The chemotherapy components provide cytotoxic effects through DNA alkylation (carboplatin, temozolomide), topoisomerase II inhibition (etoposide), or antimetabolite activity (capecitabine). This specific combination is being evaluated by Shanghai Chest Hospital as a first-line treatment for patients with pulmonary neuroendocrine tumors to determine if the addition of chemotherapy enhances the efficacy of surufatinib monotherapy.
- Other names
- surufatinib + ECsurufatinib + CAPTEMsurufatinib + etoposide + carboplatinsurufatinib + capecitabine + temozolomide
02
Targets
CSF1R (Macrophage colony-stimulating factor receptor)FGFR1 (Fibroblast growth factor receptor 1)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)DNATOP2A (DNA topoisomerase II)TS (Thymidylate synthase)
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