sutherlandia frutescens extract

Sutherlandia frutescens extract is a botanical preparation derived from a South African legume traditionally used in indigenous medicine to treat a variety of conditions, including cancer, HIV/AIDS, and inflammatory diseases. The extract contains several bioactive compounds such as L-canavanine, pinitol, GABA, and sutherlandiosides. Research indicates that the extract may exert antineoplastic effects by inhibiting the Hedgehog (Hh) signaling pathway, a key regulator of cell differentiation and proliferation that is often dysregulated in cancers. Specifically, it has been shown to repress the expression of Hh-responsive genes, including the transcription factor Gli1 and the receptor Ptch1, in prostate cancer models. While widely available as a dietary supplement, its clinical application as a standardized therapeutic agent remains under investigation.

Brand names

Phyto Nova Sutherlandia

Other names

Lessertia frutescensCancer bushKankerbosBalloon peaSutherlandia