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Suyin Jiedu Granule
- Development stage
- Unknown
- Lead developer
- Jiangsu Provincial Hospital of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Suyin Jiedu Granule (SYJD) is a Traditional Chinese Medicine (TCM) compound formulation developed by the Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine) specifically for the treatment of chronic kidney disease (CKD), including IgA nephropathy and diabetic kidney disease. The formula is based on the TCM principles of tonifying the spleen and kidney while clearing heat and detoxifying. It is primarily used to reduce proteinuria and delay the progression of renal failure. Research indicates that SYJD exerts its therapeutic effects by inhibiting the TGF-beta1/Smad signaling pathway, which is a key driver of renal fibrosis, and by suppressing the activation of the NLRP3 inflammasome to reduce inflammatory damage in the kidneys. Additionally, it has been shown to modulate the gut microbiota, potentially influencing the gut-kidney axis to improve metabolic profiles in CKD patients. It is currently utilized as a hospital-made preparation and has been the subject of several clinical trials in China.
- Brand names
- Suyin Jiedu granules
- Other names
- Suyin Jiedu KeliSuyin Jiedu formulaSYJD Granule
02
Targets
SMAD3 (SMAD family member 3)TGFB1 (Transforming growth factor Beta-1 proprotein)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)
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