Drug intelligence / Profile preview

svetol

Development stage
Unknown
Lead developer
Givaudan
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Svetol is a decaffeinated green coffee bean extract (*Coffea canephora robusta* P.) standardized to contain over 45% chlorogenic acids. It is primarily used as a dietary supplement for weight management and body composition improvement. The extract's mechanism of action involves the inhibition of glucose-6-phosphatase, which reduces glucose release from the liver into the blood, and the stimulation of lipolysis in adipocytes, leading to the liberation of free fatty acids. Unlike many other green coffee extracts, Svetol is specifically processed to maintain a high ratio of specific chlorogenic acids while removing caffeine, thereby avoiding stimulant-related side effects.

Brand names
Svetol
Other names
green coffee bean extractdecaffeinated green coffee bean extractGCE
02

Targets

G6PC1 (Glucose 6-phosphatase alpha)

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