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SVT-1B149
- Development stage
- Unknown
- Lead developer
- Servatus Biopharmaceuticals
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
SVT-1B149 is a live biotherapeutic product (LBP) developed by Servatus Biopharmaceuticals. It is an orally administered consortium of multiple bacterial strains designed to treat conditions associated with the microbiome. [3] The therapy aims to modulate the gastrointestinal microbiome to regulate inflammatory signals and immune responses. [3] SVT-1B149 has been investigated in a Phase I clinical trial for the treatment of chronic functional constipation and irritable bowel syndrome with constipation (IBS-C). [1, 2, 3] Each 10 mL oral dose contains 15 billion colony-forming units (CFU) of the bacterial species. [2]
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