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SVT-XCLEAR
- Development stage
- Discontinued
- Lead developer
- Servatus Biopharmaceuticals
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Topical
01
Overview
SVT-XCLEAR is an investigational live biotherapeutic product (LBP) developed by Servatus Limited, an Australian biotechnology company. It was designed as a microbial-based therapy for the treatment of mild-to-moderate atopic dermatitis and associated Staphylococcus infections. The drug consists of specific bacterial strains selected for their ability to inhibit the growth of pathogenic bacteria, particularly *Staphylococcus aureus*, and to modulate the host's immune and inflammatory responses. An open-label exploratory clinical trial (ACTRN12621000543819) was planned to evaluate the safety and efficacy of SVT-XCLEAR in both children and adults, but the study was subsequently withdrawn before completion. The therapy represents a non-antibiotic approach to managing skin dysbiosis and chronic inflammation.
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