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sw iv-134
- Development stage
- Preclinical
- Lead developer
- Washington University School of Medicine
- Modality
- Peptides, Small Molecules
- Administration
- Intraperitoneal (preclinical Studies)
01
Overview
SW IV-134 is a targeted **small molecule conjugate** that links a sigma-2 ligand with a peptide mimetic of SMAC (second-mitochondria activator of caspases). The sigma-2 ligand facilitates cancer cell selectivity by targeting sigma-2 receptors, which are overexpressed in several cancer types, including ovarian and pancreatic cancer[1][2]. The SMAC mimetic portion interferes with inhibitor of apoptosis proteins (IAPs), promoting caspase activation and apoptosis. SW IV-134 is a pure enantiomer, structurally derived from SW IV-52, and shows increased internalization efficacy and cytotoxicity compared to prior analogs such as SW III-123[1].
- Other names
- sw iv-134
02
Targets
TMEM97 (Sigma-2 receptor complex (TMEM97/PGRMC1))BIRC3 (Baculoviral IAP repeat-containing protein 3)XIAP (Baculoviral IAP repeat-containing protein 4)BIRC2 (Cellular inhibitor of apoptosis protein 1)
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