SY-7021

SY-7021: sourced facts only. name: "Here, we identified a highly potent and selective DNA-PK inhibitor, SY-7021, with an IC50 value of 0.242 nM on DNA-PK kinase and high selectivity on ATM and ATR (greater than 400-fold) in biochemical assays." [DOI:10.1158/1538-7445.am2024-4540]; target: "Here, we identified a highly potent and selective DNA-PK inhibitor, SY-7021, with an IC50 value of 0.242 nM on DNA-PK kinase and high selectivity on ATM and ATR (greater than 400-fold) in biochemical assays." [DOI:10.1158/1538-7445.am2024-4540]; developer: "1Shouyao Holdings Co., Ltd, Beijing, China." [DOI:10.1158/1538-7445.am2024-4540]; stage: "In a subcutaneous NCI-H1703 xenograft tumor model, SY-7021 administered orally twice daily achieved dose-dependent tumor growth inhibition in vivo, with a tumor growth inhibition (TGI) of 105.6% at 60 mg/kg and no significant weight loss was observed." [DOI:10.1158/1538-7445.am2024-4540]