SyBV^STING

SyBV^STING is a drug delivery system composed of synthetic bacterial extracellular vesicles (SyBV) loaded with a STimulator of InterferoN Genes (STING) agonist. SyBV are generated from Escherichia coli membranes by lysozyme and ionic stress, resulting in nanovesicles largely devoid of cytosolic proteins and nucleic acids to reduce inflammatory side effects. When loaded with a STING agonist, SyBV^STING synergistically activates dendritic cells via the STING pathway, inducing robust type I interferon (e.g., IFN-β) and enhancing tumor-specific immunity. In preclinical models, administration of SyBV^STING promotes T cell infiltration into tumors and suppresses melanoma and colon cancer growth. Toxicology studies reported no histopathological concerns, supporting further development as an immuno-oncology therapy[1][3][5][7].

Other names

synthetic bacterial vesicle loaded with STING agonistSyBV loaded with STING agonist