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sym024
- Development stage
- Phase 2
- Lead developer
- Symphogen
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Vaccines & Immunotherapeutics, Covalent Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Sym024 is a human monoclonal antibody that targets CD73 (also known as 5'-nucleotidase or NT5E), an ectoenzyme involved in the production of immunosuppressive adenosine in the tumor microenvironment. By inhibiting CD73, Sym024 aims to reduce adenosine-mediated immune suppression and enhance antitumor immune responses. The drug is being developed primarily for advanced solid tumors and non-small cell lung cancer. It has been studied both as monotherapy and in combination with Sym021 (an anti-PD-1 antibody). Preclinical data suggest that combining CD73 inhibition with PD-1 blockade may synergistically reverse immune suppression and promote T cell activation. The developer is Symphogen (a subsidiary of Servier)[1][3][4][5][8].
- Other names
- anti-CD73 monoclonal antibody Sym024anti-CD-73 monoclonal antibody Sym024anti-CD 73 monoclonal antibody Sym024
02
Targets
NT5E (Cluster of Differentiation 73)
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