SYN-010

SYN-010 is a proprietary, modified-release formulation of lovastatin lactone designed to treat irritable bowel syndrome with constipation (IBS-C). It works by targeting methane production in the gut, which is believed to be a major underlying cause of IBS-C symptoms. The mechanism of action targets intestinal methane production, which has been linked to pain, bloating, and constipation in IBS-C patients. SYN-010 is formulated to act primarily in the intestinal lumen while avoiding systemic absorption of the cholesterol-lowering metabolite form of lovastatin. The drug is delivered via hydroxypropyl methylcellulose (HPMC) capsules filled with enteric-coated tablets that release lovastatin at different intestinal pH values. This design allows the tablets to pass through the stomach unchanged, releasing a small amount of lovastatin into the duodenum and the majority of the dose into the ileocecal junction and colon.