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syn-RA16
- Development stage
- Preclinical
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
syn-RA16 is a chemically synthesized RNA aptamer specifically designed to target and inhibit non-small cell lung cancer (NSCLC) cells by binding to and internalizing into the NCI-H460 cell line. It accumulates at tumor sites and inhibits cancer cell viability in a dose-dependent manner. syn-RA16 was developed as a drug development-optimized version of the originally in vitro–transcribed RA16 (trans-RA16); its synthetic production allows for chemical modifications to enhance drug-like properties. Its high selectivity and strong tumor retention suggest utility as a targeted therapy or cancer diagnostic tool[1][4][7].
- Other names
- synthetic RA16syn RA16
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