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SYNT-212

Development stage: Preclinical
Lead developer: Syntis Bio
Modality: Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes
Administration: Oral

Overview

SYNT-212 is an oral enzyme replacement therapy being developed by Syntis Bio for the treatment of homocystinuria, specifically classical homocystinuria caused by cystathionine beta-synthase (CBS) deficiency. The therapeutic candidate consists of a gastrointestinal (GI)-stable methionine gamma-lyase (MGL) enzyme that utilizes the proprietary DIGEST™ (also known as SYNT™) technology platform for extended delivery. SYNT-212 is designed to degrade methionine within the gastrointestinal tract, facilitating both dietary and enterohepatic elimination. By reducing the absorption and reabsorption of methionine in the gut, the therapy aims to lower systemic levels of methionine and its toxic metabolite, homocysteine. SYNT-212 represents a next-generation advancement over the company's SYNT-202 program, offering a more sustained mechanism of action through its extended-release formulation.

Other names: methionine gamma-lyaseMGL

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