Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
synthetic preimplantation factor
- Development stage
- Phase 1
- Lead developer
- BioIncept
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Peptides, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Subcutaneous (investigational Studies)
01
Overview
Synthetic preimplantation factor (sPIF) is a chemically synthesized peptide that is an exact analog of the naturally occurring preimplantation factor (PIF), a 15-amino acid peptide secreted by viable embryos during early embryonic development. sPIF mimics the biological activity of endogenous PIF and acts primarily through paracrine signaling to modulate immune responses and promote maternal tolerance without causing immune suppression. It upregulates integrins on the endometrial wall to facilitate embryo implantation and has demonstrated anti-inflammatory, neuroprotective, and trophic effects in various preclinical models. sPIF is being investigated for therapeutic use in autoimmune diseases such as autoimmune hepatitis, prevention of graft-versus-host disease, recurrent pregnancy loss, and perinatal brain injury[1][2][3][4][5][6][7][8].
- Other names
- synthetic PreImplantation FactorsPIFPIF*PreImplantation Factor (synthetic)synthetic PIF
02
Targets
BAG3 (Bcl2-associated athanogene 3)HSP90 (Heat shock protein 90 chaperone complex)ACTA2 (Alpha-smooth muscle actin)TUBB (Tubulin (alpha and beta subunits))P4HB (Protein disulfide-isomerase)
Beyond the preview
Go deeper on synthetic preimplantation factor.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on synthetic preimplantation factor.