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SynuClean-D
- Development stage
- Preclinical
- Lead developer
- Universitat Autònoma de Barcelona
- Modality
- Small Molecules
01
Overview
SynuClean-D (SC-D) is a preclinical small molecule inhibitor of alpha-synuclein (\u03b1-synuclein) aggregation. Identified through a high-throughput screen of a chemical library, SynuClean-D binds to cavities in mature amyloid fibrils, disrupting their structure, preventing the propagation of protofibrils, and inhibiting the aggregation of wild-type \u03b1-synuclein as well as its familial variants (A30P and H50Q). In animal models of Parkinson's disease, such as *Caenorhabditis elegans*, SynuClean-D has demonstrated neuroprotective effects by reducing \u03b1-synuclein toxicity and rescuing dopaminergic neurons from degeneration. It is currently developed as a research-use-only compound for the study of Parkinson's disease and other synucleinopathies.
- Other names
- 2-hydroxy-5-nitro-6-(3-nitrophenyl)-4-(trifluoromethyl)nicotinonitrile5-nitro-6-(3-nitrophenyl)-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile
02
Targets
SNCA (Alpha-synuclein)
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