Drug intelligence / Profile preview

Systaflam

Development stage
Unknown
Lead developer
Systopic Laboratories
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Systaflam is a brand of multi-ingredient pain-relieving and muscle-relaxing formulations developed and marketed by Systopic Laboratories. It is available in several formulations, including topical gels, topical sprays, and oral capsules/tablets, primarily indicated for the management of musculoskeletal pain, muscle spasms, joint stiffness, and inflammatory conditions such as osteoarthritis, rheumatoid arthritis, sprains, and sports injuries. The topical gel formulation typically combines the non-steroidal anti-inflammatory drug (NSAID) diclofenac with the muscle relaxant mephenesin and counterirritants like menthol, methyl salicylate, and turpentine oil. The oral MR (muscle relaxant) formulation combines diclofenac with the muscle relaxant thiocolchicoside, while the oral tablet formulation combines diclofenac with paracetamol and chlorzoxazone. Together, these active ingredients work synergistically to alleviate pain, reduce inflammation, and relieve muscle spasms.

Brand names
SystaflamSystaflam GelSystaflam MRSystaflam Spray
02

Targets

GABRR (GABA-A receptor subunit rho)Glycine receptorPGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TRPM8 (Transient receptor potential cation channel subfamily M member 8)GABAA (Gamma-aminobutyric acid receptor)NMDAR (Glutamate receptor ionotropic, NMDA)

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