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SZR104
- Development stage
- Preclinical
- Lead developer
- University of Szeged
- Modality
- Small Molecules
- Administration
- Intraperitoneal
01
Overview
SZR104 (SZR-104) is a brain-penetrable synthetic kynurenic acid (KYNA) analog developed by the University of Szeged. Unlike endogenous kynurenic acid, which has very limited blood-brain barrier (BBB) permeability, SZR104 is highly permeable to the BBB due to its C-3 aminoalkylation. SZR104 acts as an agonist of the aryl hydrocarbon receptor (AHR) and exhibits potent anti-inflammatory, neuroprotective, and anticonvulsant properties. It has been shown to inhibit microglial activation, reduce the production of pro-inflammatory cytokines (such as TNF-alpha and IL-6), and promote the expression of anti-inflammatory markers like TSG-6. SZR104 is under preclinical investigation for the treatment of neurodegenerative and neuroinflammatory disorders, including epilepsy, Alzheimer's disease, and other tauopathies.
- Other names
- N-(2-(dimethylamino)ethyl)-3-(morpholinomethyl)-4-hydroxyquinoline-2-carboxamide
02
Targets
AHR (Aryl hydrocarbon receptor)NMDAR (Glutamate receptor ionotropic, NMDA)TNFA (Tumor necrosis factor alpha (soluble))
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