T-3775440

T-3775440 is a highly selective, irreversible small molecule inhibitor of the chromatin demethylase **lysine-specific demethylase 1 (LSD1, also known as KDM1A)**. It acts by binding to and inactivating LSD1, thereby disrupting its interactions with SNAG domain-containing transcription factors such as **INSM1** and **GFI1B**. This inhibition impairs the transcriptional regulation of neuroendocrine-associated genes and induces differentiation and antiproliferative effects in cancer cells. T-3775440 has demonstrated potent efficacy in preclinical models of **small-cell lung cancer (SCLC)** and **acute myeloid leukemia (AML)**, where it disrupts LSD1 complexes crucial for cell growth and survival[1][2][3][5].

Other names

T-3775440 hydrochlorideT3775440 hydrochlorideT 3775440 hydrochloride