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T-401

Development stage: Unknown
Lead developer: Tune Therapeutics
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

T-401, specifically in its radiolabeled form as [18F]T-401, is a positron-emission tomography (PET) imaging agent. This radiopharmaceutical is designed to selectively and reversibly bind to monoacylglycerol lipase (MAGL), a key enzyme involved in the endocannabinoid system and inflammatory processes within the central nervous system. It serves as a diagnostic tool to quantify MAGL enzyme availability and occupancy in the brain, aiding in the validation of therapeutic MAGL inhibitors and the investigation of MAGL levels in various physiological and pathological conditions.

Targets

MGLL (Monoacylglycerol lipase)

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