T-cell-replete peripheral blood stem cells

T-cell-replete peripheral blood stem cells refers to **allogeneic or autologous peripheral blood stem cell grafts that have not undergone ex vivo T-cell depletion**. They are collected from the donor's blood after mobilization (often with granulocyte colony-stimulating factor, G-CSF) and contain a full complement of T-cells along with hematopoietic stem cells. This product is used in **hematopoietic stem cell transplantation (HSCT)**, particularly in settings where a rapid immune reconstitution is desired, such as for patients with high-risk or refractory hematologic malignancies (e.g., acute leukemias, lymphomas). By retaining T-cells, these grafts can promote faster immune recovery but may also increase the risk of graft-versus-host disease (GvHD); consequently, intensive in vivo immunosuppressive prophylaxis (e.g., post-transplantation cyclophosphamide or anti-thymocyte globulin) is used to mitigate this risk. Clinical protocols vary based on donor type (matched sibling, matched unrelated, or haploidentical), donor-recipient compatibility, and disease indication[1][2][5].

Other names

T cell-replete PBSCT cell-replete peripheral blood stem cell graftunmanipulated peripheral blood stem cells