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T-DEN-Post-Transfection F19
- Development stage
- Unknown
- Lead developer
- Walter Reed Army Institute of Research
- Modality
- Live Attenuated Vaccines → Live Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
T-DEN-Post-Transfection F19 is a live-attenuated tetravalent dengue virus (DENV) vaccine formulation. It contains four dengue virus serotypes: DENV-1 (West Pac 74, 45AZ5, PDK-27), DENV-2 (S16803, PDK-50), DENV-3 (CH53489, PDK-20), and DENV-4 (341750, PDK-6). The vaccine was developed through a re-derivation process where purified viral RNA from each strain was extracted and used to transfect FRhL cells. The F19 formulation is similar to the F17 formulation but contains approximately 4-fold less DENV-4 than the F17 formulation. The vaccine is pre-mixed, freeze-dried, and presented in single-dose vials, with sterile water used for reconstitution before injection.
- Other names
- F19 TDEN vaccineF-19 TDEN vaccineF 19 TDEN vaccine
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