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T-DEN vaccine
- Development stage
- Phase 2
- Lead developer
- U.S. Army Medical Research and Development Command
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
The T-DEN vaccine is a live-attenuated tetravalent dengue virus vaccine developed by the Walter Reed Army Institute of Research (WRAIR) in collaboration with GSK. It is designed to provide protection against all four dengue virus serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). The vaccine consists of four specific live attenuated virus strains: DENV-1 (45AZ5, PDK-27), DENV-2 (S16803, PDK-50), DENV-3 (CH53489, PDK-20), and DENV-4 (341750, PDK-6), which were attenuated through serial passage in cell culture. It has been evaluated in Phase 1 and Phase 2 clinical trials to assess safety and immunogenicity in healthy adults, using different formulations such as F17 and F19.
- Other names
- WRAIR live attenuated tetravalent dengue vaccineWRAIR dengue vaccineTetravalent Dengue Vaccine
02
Targets
DENV (Flavivirus antigens and proteins)
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