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T-oligo
- Development stage
- Preclinical
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
T-oligo is a single-stranded deoxyribonucleic acid with partial sequence homology to human telomeric DNA. It has been shown to elicit cytostatic and/or cytotoxic effects in multiple cancer cell types by interfering with normal telomeric structure and forming G-quadruplex structures, thereby inducing genomic stress and activating DNA damage response pathways. T-oligo is particularly noted for its effectiveness in prostate cancer cells while being non-toxic to normal primary cells.
- Other names
- telomere-mimetic oligonucleotide
02
Targets
POT1 (Protection of telomeres protein 1)G-overhang (Telomeric G-overhang DNA structure)TBPL1 (Telomeric repeat binding factor 2)
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