Drug intelligence / Profile preview

T-V7

Development stage
Phase 4
Lead developer
National Taiwan University Hospital
Modality
Small Molecules
Administration
Oral
01

Overview

**T-V7** is a 7-day oral *Helicobacter pylori* eradication regimen evaluated in the National Taiwan University Hospital multicenter randomized pilot trial NCT04713670. It combines the potassium-competitive acid blocker vonoprazan with clarithromycin-XL and amoxicillin. Vonoprazan provides potent gastric acid suppression through reversible, potassium-competitive inhibition of gastric hydrogen-potassium ATPase, while clarithromycin inhibits bacterial protein synthesis and amoxicillin inhibits bacterial cell-wall synthesis. T-V7 is a protocol-defined co-administration regimen rather than a distinct marketed fixed-dose product. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04713670))

Brand names
Voquezna Triple PakVonopion
Other names
7-day vonoprazan-based triple therapyvonoprazan + clarithromycin-XL + amoxicillin
02

Targets

PBP (Penicillin-binding protein family)ATP4A (Potassium–transporting ATPase alpha chain 1)23S rRNA (23S ribosomal RNA)

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