T12 nanofiber

T12 nanofiber is a self-assembled peptide-based supramolecular nanofiber designed to target CD38, a glycoprotein overexpressed in multiple myeloma (MM). Developed by researchers at the Washington University School of Medicine (Mallinckrodt Institute of Radiology) and the Van Andel Institute, the T12 nanofiber features a CD38-binding peptide epitope conjugated to a 12-carbon lipid tail (lauric acid/dodecanoic acid). The length of the lipid tail dictates the nanofiber's morphology, forming 6+7 and 7+7 assemblies with intercalated, single-layer lipid cores that optimize the presentation and conformational flexibility of the peripheral CD38-binding residues. This polyvalent presentation significantly enhances binding avidity compared to soluble monomeric peptides, achieving sub-nanomolar to low nanomolar affinity. The T12 nanofiber can be efficiently radiolabeled with Copper-64 (64Cu) for positron emission tomography (PET) imaging, offering a highly stable and sensitive diagnostic tool for the detection and characterization of CD38-positive malignancies such as multiple myeloma.

Other names

T12 type 1 nanofiberT-12 type 1 nanofiberT 12 type 1 nanofiberT12 type 2 nanofiberT-12 type 2 nanofiberT 12 type 2 nanofiberT12 type1 nanofiberT-12 type1 nanofiberT 12 type1 nanofiberT12 type2 nanofiberT-12 type2 nanofiberT 12 type2 nanofiber