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T22-GFP-H6

Development stage: Unknown
Modality: Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Nanoparticles → Drug Delivery Systems
Administration: Intravenous

Overview

T22-GFP-H6 is a self-assembling recombinant fusion protein nanoparticle developed as a targeted drug delivery platform for cancer therapy. It consists of the **T22 peptide** (a polyphemusin II derivative that is a selective ligand for CXCR4), **GFP** (green fluorescent protein, typically used for biodistribution tracking), and a **hexahistidine (H6) tag** for purification. The T22 component binds selectively to the **CXCR4 receptor**, which is overexpressed in cancer stem cells of various human tumors, including colorectal cancer. This allows the nanoparticle to selectively bind and internalize into CXCR4+ cancer cells, delivering cytotoxic agents (when conjugated) directly to metastatic and tumor cells with minimal off-target toxicity.

Brand names: T22-GFP-H6T-22-GFP-H6T 22-GFP-H6
Other names: T22-GFP-H6T-22-GFP-H6T 22-GFP-H6

Targets

CXCR4 (C-X-C motif chemokine receptor 4)

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