Drug intelligence / Profile preview

T320

Development stage
Phase 1
Lead developer
Nanolattix
Modality
Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

T320 is an antibody-drug conjugate (ADC) targeting tissue factor (TF), a transmembrane receptor that is aberrantly expressed on the surface of various malignant solid tumors. Developed by Nanolattix Biotechnology, T320 is designed to bind specifically to TF-expressing cancer cells, leading to internalization of the complex and subsequent release of a cytotoxic payload to induce cell death. The drug is currently being evaluated in Phase I clinical trials for its safety, pharmacokinetics, and preliminary efficacy in patients with advanced solid tumors, including cervical cancer, ovarian cancer, pancreatic cancer, and non-small cell lung cancer. T320 has received Orphan Drug Designation (ODD) from the FDA for the treatment of pancreatic cancer and holds patents in China, the United States, and Australia.

Other names
T320 for InjectionT-320 for InjectionT 320 for Injection
02

Targets

F3 (Tissue factor)

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