t4 endonuclease v

T4 endonuclease V is a DNA repair enzyme originally derived from the T4 bacteriophage. It specifically targets cyclobutane pyrimidine dimers (CPDs), which are the most prevalent DNA lesions induced by ultraviolet (UV) radiation. The enzyme possesses a dual catalytic mechanism: it acts as a DNA glycosylase, cleaving the glycosidic bond of the 5' pyrimidine of the dimer, followed by an AP-lyase activity that cleaves the phosphodiester bond. In clinical development, the enzyme is typically encapsulated in pH-sensitive liposomes (referred to as T4N5 liposomes) to enable delivery into the cytoplasm and subsequently the nuclei of keratinocytes. It has been primarily investigated as a chemopreventive agent to reduce the incidence of actinic keratosis and non-melanoma skin cancers, particularly in high-risk populations such as patients with xeroderma pigmentosum (XP).

Brand names

Dimericine

Other names

denV gene productT4N5 liposome lotionT-4N5 liposome lotionT 4N5 liposome lotionCyclobutane pyrimidine dimer-DNA glycosylaseT4-VT-4-VT 4-V