t900607

T900607 is a pentafluorophenylsulfonamide compound with potential antineoplastic activity. It inhibits tubulin polymerization by binding irreversibly to colchicine binding sites, resulting in cell cycle arrest and apoptosis. Unlike vinca alkaloids, T900607 uniquely causes specific covalent modification of β-tubulin (β1, β2, and β4 isotypes). The compound is not a substrate for p-glycoprotein drug pump and has demonstrated activity in preclinical multidrug resistance models. It was developed by Tularik Inc. and evaluated in clinical trials for liver and gastric cancers.

Other names

benzenesulfonamide, n-(3-((aminocarbonyl)amino)-4-methoxyphenyl)-2,3,4,5,6-pentafluoro-261944-52-9unii-ic9o2ht1x1unii-ic-9o2ht1x1unii-ic 9o2ht1x1