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TA-HPV
- Development stage
- Phase 2
- Lead developer
- Xenova Group
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, Vaccines & Immunotherapeutics
- Administration
- Parenteral (injection)
01
Overview
TA-HPV is an investigational therapeutic vaccine designed to treat human papillomavirus (HPV)-associated diseases. It is a recombinant vaccinia virus-based vaccine engineered to express the E6 and E7 oncoproteins from HPV types 16 and 18, which are high-risk strains associated with cervical and other anogenital cancers. The vaccine aims to stimulate a cytotoxic T lymphocyte (CTL) immune response specifically targeting cells expressing these viral oncoproteins, thereby promoting the clearance of HPV-infected or transformed cells. TA-HPV has been studied primarily for its potential in treating cervical cancer and related neoplasias[4][7].
- Other names
- Human Papillomavirus tumor antigen vaccine
02
Targets
HPV16 E7 (Human papillomavirus 16 E7 protein)HPV16 E6 oncoproteinHPV18 E7
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