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taberminogene vadenovec
- Development stage
- Discontinued
- Lead developer
- Premier Biotech
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, Gene Therapies
- Administration
- Local, Intraoperative, Topical
01
Overview
Taberminogene vadenovec is a gene therapy developed for the prevention of complications due to neointimal hyperplasia in certain vascular anastomoses, such as those occurring after vascular interventions. It consists of a gene-based medicine delivered locally via a device. The drug works by stimulating the expression of vascular endothelial growth factor D (VEGF-D), promoting revascularization and inhibiting restenosis at the site of intervention. Its primary indication has been for the prevention or treatment of vascular restenosis[1][2][3][4][6]. The product was originally developed by Ark Therapeutics Group and has reached Phase 3 clinical trials but is now discontinued for this indication[3][8].
- Brand names
- Trinam
- Other names
- taberminogene vadenovecTrinamEG004EG-004EG 004
02
Targets
VEGFD (Vascular endothelial growth factor D)
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