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Tabirafusp tedromer is an investigational recombinant fusion protein developed by Kodiak Sciences for the treatment of retinal diseases. It is a bispecific molecule that acts as a dual inhibitor of interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF), designed to target both inflammatory and angiogenic pathways implicated in conditions such as neovascular (wet) age-related macular degeneration (AMD). The drug utilizes an antibody biopolymer conjugate (ABC) platform, aiming to provide durable efficacy with less frequent dosing compared to existing therapies. Tabirafusp tedromer is currently in phase 3 clinical trials for wet AMD, with additional development in earlier phases for diabetic macular oedema and preclinical studies for dry AMD[2][4][6][7].
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