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TAC chemotherapy
- Development stage
- Phase 4
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
TAC chemotherapy is a combination regimen consisting of three cytotoxic drugs: docetaxel (a taxane), doxorubicin (an anthracycline), and cyclophosphamide (an alkylating agent). It is primarily used as adjuvant or neoadjuvant therapy for breast cancer, especially in cases with a higher risk of recurrence. Each drug in the combination attacks cancer cells through different mechanisms: - Docetaxel disrupts microtubule function, inhibiting cell division. - Doxorubicin intercalates into DNA and inhibits topoisomerase II, causing DNA damage and apoptosis. - Cyclophosphamide crosslinks DNA strands, preventing cell replication. The combination exploits these complementary mechanisms to maximize tumor cell kill. The regimen is typically administered intravenously every 3 weeks for six cycles[1][2][3][4][7].
- Brand names
- Adriamycin (doxorubicin)Cytoxan (cyclophosphamide)Taxol (paclitaxel)Taxotere (docetaxel)
- Other names
- Taxotere Adriamycin Cyclophosphamidedocetaxel doxorubicin cyclophosphamideTAC regimen
02
Targets
DNATOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))
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