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TACE + HAIC
- Development stage
- Unknown
- Lead developer
- Sun Yat-sen University
- Modality
- Small Molecules
- Administration
- Intra-arterial
01
Overview
TACE-HAIC is a combination treatment protocol developed and investigated by Sun Yat-sen University for the management of hepatocellular carcinoma (HCC), particularly for patients with potentially resectable tumors. The protocol integrates Transarterial Chemoembolization (TACE), which involves the intra-arterial delivery of chemotherapy (typically epirubicin) mixed with lipiodol followed by mechanical embolization of the tumor's blood supply, with Hepatic Arterial Infusion Chemotherapy (HAIC) using a FOLFOX-based regimen (oxaliplatin, leucovorin, and 5-fluorouracil). This dual approach is designed to maximize the local concentration of cytotoxic agents within the liver and induce tumor shrinkage, thereby serving as a conversion therapy to increase the rates of successful surgical resection.
- Other names
- TACE-HAIC protocolTransarterial Chemoembolization plus Hepatic Arterial Infusion ChemotherapyTACE-HAIC-Sun Yat-sen University-hepatocellular carcinoma
02
Targets
TOP2A (DNA topoisomerase II)DNATS (Thymidylate synthase)
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