Drug intelligence / Profile preview

tacrolimus + ripertamab

Development stage
Unknown
Lead developer
Sinocelltech
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Oral, Intravenous
01

Overview

Tacrolimus + ripertamab is a combination therapy being investigated for the treatment of kidney diseases, particularly minimal change disease (MCD) and membranous nephropathy. Tacrolimus is a calcineurin inhibitor that suppresses T-cell activation, while ripertamab is a recombinant human-mouse chimeric anti-CD20 monoclonal antibody similar to rituximab. The combination aims to provide higher remission rates, lower recurrence rates, and fewer side effects compared to standard treatments for these conditions.

02

Targets

FKBP1ACD20 (B-lymphocyte antigen CD20)CN (Calcineurin)

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