Drug intelligence / Profile preview

tadalafil

Development stage
Approved
Lead developer
Eli Lilly
Modality
Small Molecules
Administration
Oral
01

Overview

Tadalafil is a selective phosphodiesterase 5 (PDE5) inhibitor used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). It works by blocking the enzyme PDE5, leading to increased levels of cyclic guanosine monophosphate (cGMP), which causes smooth muscle relaxation and increased blood flow in specific tissues. For ED, this results in improved erectile function; for BPH, it relaxes muscles in the prostate and bladder; for PAH, it relaxes blood vessels in the lungs to lower blood pressure. Tadalafil was originally developed by ICOS Corporation and later co-developed with Eli Lilly. It is marketed under several brand names including Cialis for ED/BPH and Adcirca for PAH[1][3][4][5][8].

Brand names
CialisAdcircaAlyqTadliqChewtadzy
Other names
AdcircaAlyqTadliq
02

Targets

PDE11A (Phosphodiesterase 11A)PDE5 (Phosphodiesterase 5A)PDE6 (Phosphodiesterase 6)

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