taf12 shRNA

Taf12 shRNA is a short hairpin RNA designed to silence the expression of TATA-box binding protein associated factor 12 (Taf12), a subunit of the TFIID co-activator complex. Research conducted at Cold Spring Harbor Laboratory demonstrated that Taf12 is essential for the maintenance of acute myeloid leukemia (AML) cells. Mechanistically, Taf12 inhibition selectively suppresses the transcription of core targets of the oncogenic transcription factor Myb. This effect is mediated through the physical interaction between the histone fold domain (HFD) dimer of Taf12/Taf4a and the transactivation domain of Myb. In preclinical models, Taf12 shRNA showed potent anti-leukemic activity in vitro and in vivo without affecting normal myeloid cells, suggesting a therapeutic window for AML treatment.

Other names

Taf12 knockdownTaf-12 knockdownTaf 12 knockdownshRNA targeting Taf12