TAG72CAR T cells

TAG72CAR T cells are chimeric antigen receptor (CAR) T cells designed to target **tumor-associated glycoprotein 72 (TAG-72)**, a pan-adenocarcinoma antigen highly expressed in cancers such as ovarian, colorectal, breast, prostate, and stomach. The CAR construct utilizes a single-chain variable fragment (scFv) specific for TAG-72, often derived from the CC49 monoclonal antibody, and couples this to intracellular signaling domains including CD28 or 4-1BB and CD3ζ. Second-generation constructs enhance tumor cell recognition and killing by incorporating improved affinity scFv and optimized costimulatory regions[1][2]. These CAR-T cells are investigated primarily for solid tumors expressing TAG-72, with particular focus on ovarian and colorectal cancers. Development has included both single-targeted and dual CAR modalities to combat antigen loss and tumor escape[1]. Clinical testing has focused on safety, feasibility, and anti-tumor activity in advanced solid tumors.

Brand names

TAG72CAR T cellsTAG-72CAR T cellsTAG 72CAR T cells

Other names

TAG-72 CAR-T cellsTAG72 CAR-T cellsTAG 72 CAR-T cellsTAG-72-specific CAR T cellsTAG72-specific CAR T cellsTAG 72-specific CAR T cells